In a Phase 3 trial, the daily pill orforglipron outperformed oral semaglutide for weight loss (15-20 lbs) and cardiovascular markers. As a small molecule, it requires no refrigeration and is cheaper to scale, though 10% of users quit due to gastrointestinal side effects.

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Александра Синицына (Ночной линейный редактор)

‘Nothing is so secret in a human being that it does not have an outward sign,’ the Renaissance natural magician Paracelsus pronounced. The ‘doctrine of signatures’ held that the visible surfaces of plants revealed interior natures, essences and powers. The same applied to what was inscribed on the human hand. In traditional palmistry, the marks might be understood as God’s handiwork, indicating what people were like, or, formally distinct from theological frames, the hand’s surfaces might testify to celestial influences. Hence the mounts of Venus, Jupiter, Saturn and the Moon, the physical characteristics of each signifying aspects of human nature – sensuality, authority, steadfastness and the like – just as, in astrology, people born under the sign of Virgo tended to be detail-orientated. Palmar lines also had a geometry, and Kabbalistic palmists devised elaborate numerological schemes to decode lines, proportions and geometric relations. So the hand could be read because your body was marked with cosmic meaning in a not yet disenchanted world.

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those miseries, that proceed from the ignorance thereof, is invalid. For

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