Virtual memory is conceptually simple but potentially devastating to performance. Every memory access must go through segmentation (add segment base, check limit) and then paging (look up the page table). Naively, paging alone requires two additional memory reads per access -- one for the page directory entry, one for the page table entry.
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Source: Computational Materials Science, Volume 266
5 MacOS-like Linux distros that can rescue your old Intel Mac before support ends