That depends on the type of keyboard. Since the Alice-split design simply rotates the keys apart, typing on it feels fairly similar to the regular keyboards you’re already used to. A fully split board will take a little more adjustment, particularly if it uses thumb clusters. The enter, shift and control buttons may now be operated by your thumbs instead of your other fingers and that can be tough to get used to. It took me a full month to get completely comfortable with a fully split keyboard with thumb clusters. But now, I prefer it to typing on regular boards.
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Source: Computational Materials Science, Volume 267